Polynucleotides Skin Treatment

Polynucleotides are regenerative injectable treatments made from purified DNA fragments, most commonly derived from salmon DNA (PDRN therapy). These DNA chains are biocompatible, meaning when injected, your body recognises them and uses them to trigger natural repair.

Once injected, polynucleotides act as bio-stimulators and improve collagen and elastin production, increase hydration, and repair damaged tissue.

Unlike many other aesthetic injectables, polynucleotides target the quality and health of the skin itself. They’re essentially skin care, but from inside out.

Yes. Polynucleotides have been used in regenerative medicine and aesthetics for many year and are back by clinical studies. They are highly purified, biocompatible, and sterile.

Because they work with your own skin’s biology rather than adding artificial volume, the risk of complications is low. Side effects are generally mild and temporary, such as slight redness, swelling, or bruising at the injection site, which usually resolves within 24 hours.

Most patients see visible improvements in hydration and skin quality within a few weeks of their first session, with firmer, smoother results developing after completing a course of treatments. Results typically last 6–12 months, depending on factors like skin quality, age, and lifestyle. To maintain long-term benefits, many patients schedule a maintenance treatment once or twice a year.

Polynucleotides and dermal fillers work in different ways, so it’s not about one being “better” but rather which is right for your goals. Dermal fillers replace lost volume or contour specific areas, like the lips or cheeks. Polynucleotides, on the other hand, don’t add volume — they repair and regenerate the skin itself. They’re ideal if you want to improve under-eye hollows, fine lines, scarring, or skin quality without changing the shape of your face. In many cases, patients choose a combination approach: fillers for structure and polynucleotides for skin health.

Once injected, polynucleotides:

• Stimulate fibroblasts — the cells responsible for producing collagen and elastin.

• Improve hydration by boosting natural hyaluronic acid levels in the skin.

• Neutralise free radicals — reducing oxidative stress and protecting skin from environmental damage.

• Encourage tissue regeneration, making them effective for acne scars, sun damage, and other skin irregularities.

This multi-action process makes them a truly regenerative injectable rather than a cosmetic quick fix.

Polynucleotides can be used across the face, under-eyes, neck, décolletage, and body. The most common treatment areas are:

• Under-eyes – improving dark circles, hollowness, and crepiness.

• Face – reducing fine lines, wrinkles, and skin laxity.

• Neck and décolletage – restoring firmness and hydration to delicate skin.

• Acne scars or sun damage – encouraging tissue repair and evening skin texture.

Patients often notice their skin looks more hydrated and refreshed within 1–2 weeks of their first session. The regenerative effects — firmer skin, smoother texture, reduced fine lines — become more noticeable after completing a course of 2–3 treatments, spaced a few weeks apart. Because the results come from your body’s own repair mechanisms, they look gradual, natural, and long-lasting.

No. While both treatments improve hydration, they work differently. Skin boosters (like Profhilo or Seventy Hyal) use hyaluronic acid to attract water and deeply hydrate the skin. Polynucleotides go further by stimulating collagen, elastin, and tissue regeneration — repairing damage and improving skin structure. Patients often use polynucleotides when they want more than hydration alone, especially for concerns like under-eye crepiness or scarring.

Treatment is generally well tolerated. A fine needle or cannula is used, and a topical numbing cream can be applied for comfort. Most patients describe it as mild discomfort rather than pain. Downtime is minimal — you may experience slight redness, swelling, or bruising at the injection sites, which settles within 24–48 hours. You can usually return to work and daily activities straight after.