Treatment Guide: Collagen-boosting Injectables
JULÄINE™ Collagen Biostimulator in London & Altrincham
Julaine: Advanced Collagen Stimulation with Natural, Long-Lasting Rejuvenation
If your skin has started to feel less firm, less defined, less like it used to - you’re not imagining it. From our mid-30s onwards, collagen production naturally slows, and the structure that keeps skin lifted, smooth, and resilient gradually breaks down. The result is subtle at first: a little softening around the jawline, lines that weren’t there before, a face that looks tired even when you don’t feel it.
JULÄINE™ works with your body’s own biology to reverse this. Rather than masking the signs of ageing or adding volume from the outside, it activates your skin’s own collagen production from within and works to rebuild the structure, firmness, and contours that fade with time. The results gradually develop from your first sessions over weeks and months, and look entirely natural because they are: your own collagen, rebuilt by your own skin.
No surgery. No dramatic change overnight. Just a gradual, authentic-looking restoration of the skin you know you have.
Available with Dr Karim Ghabra in Altrincham and Harley Street, London.
from £750
Why choose JULÄINE™?
JULÄINE™ may be right for you if you’re noticing any of the following:
Skin that feels less firm or ‘bouncy’ than it used to
Softening around the jawline or early signs of jowling
Loss of definition in the cheeks or mid-face
Deeper smile lines or nasolabial folds
Skin that looks tired, dull, or crepey
Skin laxity concerns on the neck or décolletage
Facial changes following weight loss with Ozempic, Wegovy, or Mounjaro
A desire for long-lasting improvement - without the ‘filler look’
Perfect for:
Nasolabial folds
Juläine™ is a collagen biostimulator that revitalises the skin by encouraging natural collagen production. It can work to restructure and rejuvenate the deep set lines between your nose and lips.
Marionette lines
Marionette lines are vertical creases that run from the corners of the mouth down to the chin. These lines are primarily a structural issue rather than just movement-based wrinkles. Juläine™ works by rebuilding the structure below the skins surface.
Lower face lifting & jowls
Juläine™ rebuilds the collagen your skin naturally loses with age. This results in tightening of the lower face, lifting the skin and reducing signs of jowls. The results are natural and improve overtime.
Overall facial rejuvenation
Juläine™ enhances overall skin quality, rejuvenates the skin by encouraging collagen and elastin formation. This helps restore firmness, reduce wrinkles, and improve skin texture, creating a more youthful and fresh appearance.
JULÄINE™ is a next-generation collagen biostimulator - a clinically proven injectable that stimulates your skin to produce its own collagen, rather than adding a temporary filler material. It was developed in Sweden by Nordberg Medical and is CE-marked and MHRA-approved for use in the UK.
The active ingredient is poly-L-lactic acid (PLLA), a biocompatible, biodegradable material with a 50-year safety record in medicine. When injected, tiny microspheres of PLLA signal your skin’s own collagen-producing cells to get to work. Over the following weeks and months after your treatments, your skin builds new collagen around the treatment area - restoring structure, firmness, and quality from the inside out.
The collagen produced is your own. That’s why results look natural, develop gradually, and last up to two years.
What is JULÄINE™?
How does JULÄINE™ work?
Think of it like this: ageing skin isn’t just about lines and wrinkles - it’s about a loss of the underlying structure that keeps skin firm, lifted, and well-defined. Collagen is that structure. From your mid-30s, you naturally produce less and less of it.
JULÄINE™ targets this directly. Its ultra-fine microspheres physically activate the cells responsible for collagen production. This triggers a renewal process in your skin and it starts laying down fresh collagen in the treatment area, building density and firmness over time.
Unlike older collagen biostimulators that work by provoking an inflammatory response, JULÄINE™ stimulates collagen directly - a cleaner, more controlled mechanism that means more predictable results and a lower risk of side effects.
Results start to become visible a few weeks after your first session. They continue to develop throughout your treatments and beyond, with most patients seeing the full benefit around three to six months after completing treatment. Those results then last around 18 to 24 months.
Early results of patient after skin booster, results will continue to develop over time.
Your JULÄINE™ Treatment Journey with Dr Karim Ghabra
How many sessions will I need?
A full JULÄINE™ course generally consists of 3 sessions, spaced 3–4 weeks apart. This approach is intentional, each treatment builds on the last, allowing your skin to progress gradually. You’re not waiting for a single large treatment to kick in; you’re actively rebuilding collagen with every visit.
What happens during treatment?
Each session is carried out personally by Dr Karim Ghabra. After a review of your skin and progress, JULÄINE™ is injected into the targeted areas. The treatment typically takes around 30–45 minutes.
Is there any downtime?
None. Most patients return to their normal routine the same day. Some mild redness, swelling, or tenderness at the injection sites is can occur, this usually settles within a few hours. Unlike some older PLLA treatments, JULÄINE™ does not require a post-treatment massage protocol.
When will I see results, and how long will they last?
Most patients notice their skin looking firmer and more refreshed from around four weeks after their first session. Results continue to build, with the best outcomes typically visible around three to six months after completing the full course. A full course typically delivers results that last 18–24 months - significantly longer than most filler or skin booster treatments.
Natural looking results: Results that look 100% like you,because the improvement comes from your own collagen. Tt develops gradually and authentically, your friends will notice your skin looks healthy, not treated.
Long-lasting: A series of treatments can continue to improve up to 12–24 months or more depending on your treatment plan.
No downtime: Return to your day immediately. JULÄINE™ works quietly in the background while life carries on.
Rebuild your skin from within: JULÄINE™ triggers your body to produce its own collagen and elastin. It works by strengthening your skin’s internal support network rather than adding artificial fullness.
Versatile full facial rejuvenation: JULÄINE® can be used to address a range of concerns including, loss of facial volume, fine lines and wrinkles, skin laxity and sagging, loss of firmness and elasticity, texture irregularities and neck and décolletage laxity.
Clinically proven and medically safe: CE-marked, MHRA-approved, and winner of the AMWC 2026 Award for innovation. Administered personally by Dr Karim Ghabra, a qualified private GP with over 10 years of medical experience.
Why patients choose JULÄINE™
Request a Consultation for JULÄINE™
Please let us know a little more about you, your skin concerns, and treatment you are interested in.
JULÄINE™ vs Sculptra: What’s the difference?
Both JULÄINE™ and Sculptra are PLLA-based collagen biostimulators - so if you’ve had Sculptra before, the concept will be familiar. Both stimulate your skin to produce its own collagen over time, rather than adding an instant filler material. Both are available with Dr Karim.
The difference is in how they’re made, and what that means for you in practice.
JULÄINE™ uses LASYNPRO™ technology to produce PLLA microspheres that are significantly more uniform in size than those in Sculptra. More uniform particles distribute more evenly in the tissue, which means:
A lower risk of nodule formation - one of the known (though very uncommon) side effects of older PLLA products
Direct fibroblast activation, rather than relying on an inflammatory response - a cleaner mechanism with more predictable results
In short: JULÄINE™ offers the same fundamental approach as Sculptra - your body rebuilds its own collagen, with a more advanced delivery system. If you’ve had a good experience with Sculptra, JULÄINE™ builds on that. If you’ve been curious about collagen biostimulators but haven’t tried one, JULÄINE™ is an excellent starting point.
Dr Karim will help you decide which is the right fit during your consultation.
How JULÄINE™ Compares to Other Treatments
Both JULÄINE™ and Sculptra are PLLA-based collagen biostimulators - so if you’ve had Sculptra before, the concept will be familiar. Both stimulate your skin to produce its own collagen over time, rather than adding an instant filler material. Both are available with Dr Karim.
The difference is in how they’re made, and what that means for you in practice.
JULÄINE™ uses LASYNPRO™ technology to produce PLLA microspheres that are significantly more uniform in size than those in Sculptra. More uniform particles distribute more evenly in the tissue, which means:
A lower risk of nodule formation - one of the known (though very uncommon) side effects of older PLLA products
Direct fibroblast activation, rather than relying on an inflammatory response - a cleaner mechanism with more predictable results
In short: JULÄINE™ offers the same fundamental approach as Sculptra - your body rebuilds its own collagen, with a more advanced delivery system. If you’ve had a good experience with Sculptra, JULÄINE™ builds on that. If you’ve been curious about collagen biostimulators but haven’t tried one, JULÄINE™ is an excellent starting point.
Dr Karim will help you decide which is the right fit during your consultation.
Frequently Asked Questions about JULÄINE™ treatment
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JULÄINE™ is a next-generation collagen biostimulator made from poly-L-lactic acid (PLLA), manufactured in Sweden by Nordberg Medical. It works by stimulating your skin’s own fibroblast cells to produce new collagen, gradually improving firmness, texture, and skin quality over time.
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A full course consists of 3 sessions, spaced 3–4 weeks apart. The gradual approach allows collagen to build progressively with each treatment.
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Most patients notice their skin looking firmer and more refreshed from around 4–6 weeks after their first session. Results continue to develop over the course of treatment and beyond, with the best outcomes typically visible 3–6 months after completing the full course.
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Results typically last 18–24 months after a full course of JULÄINE™ treatment. Maintenance sessions can be considered after this period.
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No. There is no downtime with JULÄINE™. Some mild redness, swelling, or tenderness at the injection sites is normal and usually settles within a few days.
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Both are PLLA-based collagen biostimulators that work in a similar way. JULÄINE™ uses more advanced LASYNPRO™ microsphere technology, producing more uniform particles that deliver a more predictable collagen response with no post-treatment massage required. Dr Karim can discuss which is the better fit during your consultation.
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Yes. JULÄINE™ combines well with polynucleotides, skin boosters, and anti-wrinkle injections as part of a broader treatment plan. Dr Karim will advise on the best approach for your individual goals.
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JULÄINE™ treatment is priced from £750 per session. A full course of 3 sessions starts from £2,250. Exact pricing will be confirmed during your consultation.
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Yes. JULÄINE™ is CE-marked and MHRA-approved. It has an established clinical safety record, with peer-reviewed studies reporting a low rate of complications. Like all injectable treatments, it is administered personally by Dr Karim Ghabra, a qualified private GP with over 10 years of medical experience.
JULÄINE™ in Altrincham & London
Dr Karim offers JULÄINE™ treatment at Skin clinics in Altrincham (serving Manchester and Cheshire) and on Harley Street, London. Both offer a discreet, welcoming environment with the highest standards of safety and care.
JULÄINE™ Altrincham – serving Hale, Bowdon, Alderley Edge, Hale Barns, Knutsford, Wilmslow, Sale, Timperley, and Mobberley.
JULÄINE™ London – Harley Street, central London.